N-[isoleucinyl]-N'-[adenosyl]-diaminosufone

N-[isoleucinyl]-N'-[adenosyl]-diaminosufone is a synthetic small molecule and an analogue of isoleucyl-adenylate, structurally classified as a 5'-deoxyribonucleoside. It consists of an adenosine moiety linked via a sulfonamide group to an L-isoleucine residue. This compound has been used primarily as a biochemical tool in structural biology to mimic reaction intermediates in studies of aminoacyl-tRNA synthetases, particularly isoleucyl-tRNA synthetase (IleRS). It acts as a stable analogue of the enzyme's natural intermediate, allowing detailed investigation into the mechanism and fidelity of protein synthesis by these enzymes. There are no known therapeutic indications or clinical uses for this compound; it is considered experimental and mainly utilized in research settings.[1][2][3][5]

Other names

5'-Deoxy-5'-[(L-isoleucylsulfamoyl)amino]adenosine